Christopher J. Winrow, Matthew L. Hemming, Duane M. Allen, Gary B. Quistad, John E. Casida andCarrolee Barlow. Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. We generated mice with disruptions in Nte, the gene encoding NTE. Nte-/- mice die after embryonic day 8, and Nte+/- mice have lower activity of Nte in the brain and higher mortality when exposed to the Nte-inhibiting compound ethyl octylphosphonofluoridate (EOPF) than do wild-type mice.
Garry, Vincent F., et al. Environmental Health Perspectives Supplements Volume 110, Number 3, June 2002. We previously demonstrated that the frequency of birth defects among children of residents of the Red River Valley (RRV), Minnesota, USA, was significantly higher than in other major agricultural regions of the state during the years 1989-1991, with children born to male pesticide applicators having the highest risk. The present, smaller cross-sectional study of 695 families and 1,532 children, conducted during 1997-1998, provides a more detailed examination of reproductive health outcomes in farm families ascertained from parent-reported birth defects.
Xiaomei Ma, et al. Environmental Health Perspectives Volume 110, Number 9, September 2002. The authors present results demonstrating a strong relationship between exposure to indoor pesticides and the risk of childhood leukemia. The risk of childhood leukemia is higher with greater exposures, and it is also highest for exposures that occur during pregnancy, compared to exposures before pregnancy and after birth. These results should caution families to be extremely careful about using indoor pesticides, especially during childbearing years.
Stallones L, Beseler C.,Department of Psychology, Colorado Injury Control Research Center, Colorado State University, Fort Collins, CO 80523-1776, USA.1: Ann Epidemiol 2002 Aug;12(6):389-94
EHP Supplement 3, Vol. 110 (June 2002), pgs. 441-449. EHP Vol. 108, No. 8 (August 2000), pgs. 769-776.
A review of the study, "Subchronic Dermal Application of N,N-Diethyl m-Toluamide (DEET) and Permethrin to Adult Rats, Alone or in Combination, Causes Diffuse Neuronal Cell Death and Cytoskeletal Abnormalities in the Cerebral Cortex and the Hippocampus, and Purkinje Neuron Loss in the Cerebellum," which was published in Experimental Neurology, Volume 172, November 2001.
Gupta A, Agarwal R, Shukla GS. Hum Exp Toxicol 1999 Mar;18(3):174-179